PROTAC Linkers
PROTACs (Proteolysis Targeting Chimeric Molecules) are heterobifunctional protein degraders and promising targeted therapeutics candidates for cancer. The PROTAC linker connects two functional motifs of a PROTAC, a target protein binder and an E3 ligase recruiter.
The linker plays an important role in a PROTAC. The features of the linker (type, length, attachment position) can affect the formation of ligase:PROTAC:target ternary complex, resulting in influencing the efficient ubiquitination of the target protein and its ultimate degradation. The optimal lengths of the PROTAC linkers are reported varying from 12-carbon to over 20-carbon, and the commonly used linkers in the development of PROTACs are PEGs, Alkyl-Chain and Alkyl/ether.
PROTAC Linkers Isoform Specific Products
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PROTAC Linkers Related Products (4095)
Related Products (4095)
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PROTAC Linkers Isoform Comparison
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10-Aminodecanoic acid
0 ImagesCat. No.: HY-W105744CAS No.: 13108-19-510-Aminodecanoic acid is an alkane chain with terminal carboxlic acid and amine groups. 10-Aminodecanoic acid can be used as a PROTAC linker in the synthesis of PROTACs and other conjugation applications. The amino group (NH2) is reactive with carboxylic acids, activated NHS esters, carbonyls (ketone, aldehyde) etc. The terminal carboxylic acid can react with primary amine groups of activated NHS ester to form a stable amide bond.
![8-Boc-2,8-Diazaspiro[4.5]decane](https://file.medchemexpress.com/product_pic/hy-waa0067.gif "Click to View 8-Boc-2,8-Diazaspiro[4.5]decane Product Detail")
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Bis(2,5-dioxopyrrolidin-1-yl) succinate
0 ImagesCat. No.: HY-W018023CAS No.: 30364-60-4
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10-Aminodecan-1-ol
0 ImagesCat. No.: HY-W016829CAS No.: 23160-46-5Synonyms: 10-Amino-1-decanol
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16-Methoxy-16-oxohexadecanoic acid
0 ImagesCat. No.: HY-W460221CAS No.: 18451-85-9
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2-(Prop-2-yn-1-yloxy)tetrahydro-2H-pyran
0 ImagesCat. No.: HY-W045684CAS No.: 6089-04-9
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tert-Butyl (9-aminononyl)carbamate
0 Imagestert-Butyl (9-aminononyl)carbamate is an alkane chain with terminal amine and Boc-protected amino groups. The compound can be used as a PROTAC linker in the synthesis of PROTACs and other conjugation applications. Amine group is reactive with carboxylic acids, activated NHS esters, carbonyls (ketone, aldehyde) etc. The Boc group can be deprotected under mild acidic conditions to form the free amine.
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tert-Butyl N-{2-azaspiro[3.5]nonan-7-yl}carbamate
![tert-Butyl N-{2-azaspiro[3.5]nonan-7-yl}carbamate](https://file.medchemexpress.com/product_pic/hy-w056053.gif "Click to View tert-Butyl N-{2-azaspiro[3.5]nonan-7-yl}carbamate Product Detail")
0 ImagesCat. No.: HY-W056053CAS No.: 1434142-07-0
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Ethyl pent-4-ynoate
0 ImagesCat. No.: HY-W051986CAS No.: 63093-41-4
![Benzyl 2-oxo-7-azaspiro[3.5]nonane-7-carboxylate](https://file.medchemexpress.com/product_pic/hy-w053847.gif "Click to View Benzyl 2-oxo-7-azaspiro[3.5]nonane-7-carboxylate Product Detail")
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trans-4-[[(1,1-Dimethylethoxy)carbonyl]amino]cyclohexaneacetic acid
![trans-4-[[(1,1-Dimethylethoxy)carbonyl]amino]cyclohexaneacetic acid](https://file.medchemexpress.com/product_pic/hy-42374.gif "Click to View trans-4-[[(1,1-Dimethylethoxy)carbonyl]amino]cyclohexaneacetic acid Product Detail")
0 ImagesCat. No.: HY-42374CAS No.: 189153-10-4
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3-(tert-Butyldimethylsilyloxy)propan-1-amine
0 ImagesCat. No.: HY-W093070CAS No.: 115306-75-7
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14-Hydroxytetradecanoic acid
0 ImagesCat. No.: HY-W108232CAS No.: 17278-74-9
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tert-Butyl (4-aminobutyl)carbamate hydrochloride
0 ImagesCat. No.: HY-W012339CAS No.: 33545-98-1Synonyms: N-Boc-putrescine
